.1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) (...
Transcript of .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) (...
![Page 1: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/1.jpg)
Universitat Autònoma de Barcelona
![Page 2: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/2.jpg)
![Page 3: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/3.jpg)
![Page 4: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/4.jpg)
![Page 5: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/5.jpg)
![Page 6: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/6.jpg)
![Page 7: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/7.jpg)
i
![Page 8: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/8.jpg)
ii
![Page 9: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/9.jpg)
iii
![Page 10: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/10.jpg)
iv
![Page 11: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/11.jpg)
![Page 12: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/12.jpg)
![Page 13: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/13.jpg)
________________________________________________________________________Abreviaturas
________________________________________________________________________ 3
![Page 14: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/14.jpg)
Abreviaturas________________________________________________________________________
4________________________________________________________________________
![Page 15: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/15.jpg)
________________________________________________________________________Abreviaturas
________________________________________________________________________ 5
![Page 16: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/16.jpg)
![Page 17: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/17.jpg)
![Page 18: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/18.jpg)
![Page 19: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/19.jpg)
________________________________________________________________________Resumen
________________________________________________________________________ 9
![Page 20: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/20.jpg)
Resumen________________________________________________________________________
10________________________________________________________________________
![Page 21: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/21.jpg)
![Page 22: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/22.jpg)
![Page 23: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/23.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 13
![Page 24: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/24.jpg)
Introducción________________________________________________________________________
14________________________________________________________________________
![Page 25: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/25.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 15
![Page 26: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/26.jpg)
Introducción________________________________________________________________________
16________________________________________________________________________
![Page 27: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/27.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 17
![Page 28: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/28.jpg)
Introducción________________________________________________________________________
18________________________________________________________________________
![Page 29: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/29.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 19
![Page 30: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/30.jpg)
Introducción________________________________________________________________________
20________________________________________________________________________
![Page 31: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/31.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 21
![Page 32: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/32.jpg)
Introducción________________________________________________________________________
22________________________________________________________________________
![Page 33: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/33.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 23
![Page 34: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/34.jpg)
SÍNTOMAS TRATAMIENTOS
Síntomas primarios
Síntomas secundarios
Introducción________________________________________________________________________
24________________________________________________________________________
![Page 35: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/35.jpg)
Síntomas terciarios
________________________________________________________________________Introducción
________________________________________________________________________ 25
![Page 36: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/36.jpg)
Introducción________________________________________________________________________
26________________________________________________________________________
![Page 37: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/37.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 27
![Page 38: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/38.jpg)
CRITERIOS DE CLASIFICACIÓN DE LA EVOLUCIÓN CLÍNICA DE LA EM
Recaídas y remisiones (RR) Brotes bien definidos, a menudo con recuperación completa o casi completa. Sin progresión de la enfermedad entre ataques.
Recaídas y progresión (RP) Avance de la enfermedad con recaídas, sin recuperación entre ellas.
Primariamente progresivo (PP) Empeoramiento continuo de los síntomas neurológicos y deficiencias. Generalmente sin remisión o exacerbaciones agudas.
Secundariamente progresivo (SP) Agravamiento continuo de los síntomas. Aparece después de una etapa de RR.
Introducción________________________________________________________________________
28________________________________________________________________________
![Page 39: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/39.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 29
![Page 40: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/40.jpg)
Introducción________________________________________________________________________
30________________________________________________________________________
![Page 41: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/41.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 31
![Page 42: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/42.jpg)
Introducción________________________________________________________________________
32________________________________________________________________________
![Page 43: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/43.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 33
![Page 44: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/44.jpg)
Introducción________________________________________________________________________
34________________________________________________________________________
![Page 45: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/45.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 35
![Page 46: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/46.jpg)
Introducción________________________________________________________________________
36________________________________________________________________________
![Page 47: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/47.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 37
![Page 48: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/48.jpg)
Introducción________________________________________________________________________
38________________________________________________________________________
![Page 49: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/49.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 39
![Page 50: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/50.jpg)
Introducción________________________________________________________________________
40________________________________________________________________________
![Page 51: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/51.jpg)
Vector Material genético
Capacidad de empa-quetamiento
Tropismo Potencial inflamatorio
Forma del genoma viral en la célula
Principales limitaciones
Principales ventajas
________________________________________________________________________Introducción
________________________________________________________________________ 41
![Page 52: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/52.jpg)
Introducción________________________________________________________________________
42________________________________________________________________________
![Page 53: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/53.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 43
![Page 54: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/54.jpg)
Introducción________________________________________________________________________
44________________________________________________________________________
![Page 55: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/55.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 45
![Page 56: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/56.jpg)
Introducción________________________________________________________________________
46________________________________________________________________________
![Page 57: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/57.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 47
![Page 58: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/58.jpg)
Introducción________________________________________________________________________
48________________________________________________________________________
![Page 59: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/59.jpg)
Subgrupos de HAd Serotipos Tropismo natural predominante Receptores conocidos
A 12, 18, 31 gastrointestinal CAR
B1 3, 7, 16, 21, 50 respiratorio CD46, CD80/86, Receptor X, HSPG
B2 11, 14, 34, 35 renal CD46, CD80/86, Receptor X, HSPG
C 1, 2, 5, 6 respiratorio CAR, HSPG, MHC-I, VCAM-I, Integrinas
D 8, 9, 10, 13, 15, 17, 19, 20, 22-30, 32, 33, 36-39, 42-49, 51
ocular CAR, acido sialico, CD46
E 4 respiratorio, ocular CAR
F 40, 41 gastrointestinal CAR
G 52 gastrointestinal -----
________________________________________________________________________Introducción
________________________________________________________________________ 49
![Page 60: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/60.jpg)
Introducción________________________________________________________________________
50________________________________________________________________________
![Page 61: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/61.jpg)
________________________________________________________________________Introducción
________________________________________________________________________ 51
![Page 62: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/62.jpg)
Introducción________________________________________________________________________
52________________________________________________________________________
![Page 63: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/63.jpg)
![Page 64: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/64.jpg)
![Page 65: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/65.jpg)
________________________________________________________________________Objetivos
________________________________________________________________________ 55
![Page 66: .1 /0- · ) 4 4 ()* ! # )'#% ( # * ' ! !) () !# / #()' ! # &* ! ! *!# #( - )#' ( - ' ( ! ) !) !) ( ( ' %) ( ' , !6 Subject: Tesi doctoral. Universitat Autònoma de Barcelona ...](https://reader030.fdocumento.com/reader030/viewer/2022012909/5c5d05ae09d3f2673d8c4fd0/html5/thumbnails/66.jpg)