AB. Tetrasiklin PowerPoint Presentation
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Transcript of AB. Tetrasiklin PowerPoint Presentation
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8/20/2019 AB. Tetrasiklin PowerPoint Presentation
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ANTIBIOTIKATETRASIKLIN
DRS JUZRAL JIVAI MS, APT
FAKULTAS KEDOTERANUNIVERSITAS BAITURRAHMAH
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R1 R2 OH R3 N(CH3)2
C C CH CH CH C CH CH C – OH
CH C C C C – CO – NH3
C C C OH C
OH O OH O
R1 R2 R3
Klortetrasklin Cl CH3 HOksitetrasiklin H CH3 OH
Tetrasiklin H CH3 H
Demeklosiklin Cl H H
Doksisiklin H CH3 OH
Minosiklin N(CH3)2 H H
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Klortetrasili! H"l
Golongan Tetrasiklin pertama item!kan" iisolasi ari#treptom$%es a!reo&a%iens
'ar!t alam air (1*)" lar!tan 1 + (pH 2"3 ,3"3)"'ar!tan alam air (3-" 2. /am) 0ilang potensin$a *-+"paa pH netral an alkalis %epat iinakti&asi
katan engan protein plasma lei0 esar ari
tetrasiklin 4kskresi lei0 an$ak melal!i 4mpe!"melal!i !rin 1* +
Dig!nakan" kaps!l" in/eksi" mata" k!lit
Ositetrasili! H"l
'ar!t alam air (12)" lar!tan 1 + (pH 2"3,2"5) lar!tana lam air men/ai ker!0 karena ter/ai enapanoksitetra siklin (0irolisa) K!rang s!ka ikatan engangigi anak
6M" akti7tasn$a lei0 esar ter0aap 8se!omonasaer! ginosa" an k!rang ter0aap eerapa 8rote!s
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Tetrasili! H"l
'ar!t alam air (11-)" 'ar!tan air 1 + (pH 1"9,2"9)lar!tan alam air men/ai ker!0 karena enapan
tetrasik lin (0irolisa)" potensin$a erk!rang paa pH :2"- an r!sak se%ara lamat alam s!asana pH ; "-
6sorsi tiak komplit an tiak !m!m" era/atasorsi n$a erk!rang angan logam ml"
pemerian ? 2*- – *-- mg meng0asilkan kaarplasma 2-,3- m%g>ml (-"* /am)" t!r!n men/ai .–1-m%g ml (2 /am) an masi0 aa 1,3 m%g>ml (12 /am)"pemerian M 1-- mg" kaar plasma sampai 2 m%g>ml"an 3"= m%g> ml (2*- mg M) alam @akt! 3 – . /am
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6M" akteriostatik" spe%tr!m l!as akti& ter0aapakteri Gram 8os an Neg termas!k $ang resistenter0aap 8enisilin
Aakteri $ang sensiti& engan Tetrasiklin paa kaarterapi" aala0 Aa%ill!s ant0ra%is" Aoretella spp"Ar!%ella spp" 4%oli" Haemop0il!s spp" Klesiella spp"#ta7lo%o%i #trepto%o%%i" M$%oplasma" 4ntamoe a
0istol$ti%a" Tri %0omonas
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Ke0i!pan sel mikroa perl! sintesis protein (a lamRiosom) $ang eker/asama engan mRN6 an tRN6Riosom teriri atas 2 s!!nit $ait! Rio som 3- #
an *- # 8aa sintesis protein ke !a komponen iniakan erikatan engan rantai mRN6 men/ai riosom- #
Tetrasiklin mengikatkan iri paa riosom 3- # an
meng0alangi mas!kn$a kompleks tRN6katan protein er
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Tetrasili! Ko#$les Pos$at
M!a0 lar!t alam air (131)" lei0 %epat iasorsi aritetrasiklin HCl an kaar plasma tetrasiklin lei0 tinggi
De#elosili! H"l
'ar!t alam air (1=-)" lar!tan 1 + (pH 2"- – 3"-)" reaksialergi lei0 !m!m" reaksi &ototoksik lei0 sering ter/aiari tetrasiklin lainn$a
6sorsi oral lei0 %epat an ekskresi lei0 lamat ari Tetrasiklin HCl" kaar maksim!m alam plasma i%apai3 ,= /am an kaar e&ekti& alam plasma 2.–.9 /am lei0 lama ari Tetrasiklin" Oksi an Klortetrasiklin
Dosis oral Demekloksiklin HCl 3-- mg 2 kali se0ari meng0asilkan kaar $ang sama alam plasma engan osisoral Tetrasiklin HCl 2*- mg . kali se0ari
katan 8rotein *- + 4kskresi melal!i gin/al" empe!
Dig!nakan" Talet" %aps!l" lar!tan
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Dosisili! H"l
'ar!t alam air (13)" lar!tan 1 + (pH 2"- – 3"-)
Doksisiklin k!rang men$eakan @arna gigi (k!ranger ikatan engan Ca)
6sorsi oral lei0 %epat" tiak terpengar!0i makanan"meng0asilkan kaar plama lei0 tinggi ari Tetrasiklinkatan 8rotein sampai 5- +
tB" 1* /am (osis t!nggal)" sampai 22 /am setela0 osisi!lang 4kskresi lamat melal!i !rin" tiak aaak!m!la si engan aan$a gangg!an gin/al an sampai2* + i ekskresi melal!i &e%es alam ent!k akti&
Dig!nakan" %aps!l" lar!tan" in/eksi
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Mi!osili! H"l
'ar!t alam air
4#"
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ANTI BIOTIKA
KLORAMFE NIKOL
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"H "H OH "H%OH
R & " " & "H & "H & NH & "O & "H"l%
"H "H
Kloram&enikol R F NO2
Tiam&enikol R F CH3#O2
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Klora#'e!iol
#treptom$%es
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6nemia 0emolitika ter/ai paa pasien kek!rangan
enim gl!kosa,=,pospat e0irogenase (Genetik) Aa$iprema t!r ata! ar! la0ir apat ter/ai Gre$ #inrom
paa osis tinggi (osis 2* mg>KgAA se0ari)" ge/ala0ipotermia" per na&asan irreg!lar" sianosis" #0o%k aniik!ti engan kematian alam eerapa /am ata! 0ari
Kloram&enikol $ang lama (oral) apat menim!kan
penara0an karena epresi s!ms!m t!lang"peng!rangan ora !s!s (k!rang sintesis
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Resisten silang $ang lema0 ter/ai antara
Kloram&enikol–4ritromisin an kloram&enikol,Tetrasiklin
4nim asetil trans&erase spesi7k apat ient!k ole0
akteri (perantaraan &aktor R) $ang apat mer!sakKloram&enikol
6sorsi aik (oral)" kaar alam ara0 1- m%g>ml (2 /am" single osis 1 gram)" an iperta0ankan ; .
m%g>ml (setiap = /am" *-- mg)Distri!si l!as alam /aringan t!!0 sampai C#"(kaarn$a 3- – *- + ari kaar alam ara0) an apati&!si kealam ple!ra !i an mas!k plasenta an
mas!k sirk!lasi ara0 /aninkatan 8rotein (=- +) 4kskresi !tama melal!i !rine (9-+)" empe! (3 +)" &e%es (1 +)
Dig!nakan" kaps!l" in/eksi" mata
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Klora#'e!iol Pal#itat
Tiak lar!t alam air" oral an i0irolisa alam GTmen/ai Kloram&enikol
Klora#'e!iol Na S(si!at
'ar!t alam air (11)" lar!tan 2* + (pH =".,"-)" tiakaa e&ek 6M sampai terent!k Kloram&enikol(0irolisa)
Tia#'e!iol#!kar lar!t alam air" lar!tan /en!0 (pH *"9,"*)
Tia#'e!iol )lisi!at H"l
m!a0 lar!t alam air" lar!tan * + (pH 3"-,."*)
K!rang epresi s!ms!m t!lang" aplasi sangat /arang
6M" spektr!m l!as
6sorsi aik melal!i GT an 4kskresi ter!tamamelal!i !rin an seagian empe!
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TERIMA KASIH