Inf. Crónica Granulomas 2014
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Inflamación crónica: granulomas
Prof Carlos Ponzinibbio
Cátedra de Patología B
2014
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Robert Koch 1843-1910
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La tuberculosis es la segunda causa mundial de mortalidad, después del sida, causada por un agente infeccioso.En 2012, 8,6 millones de personas enfermaron de tuberculosis y 1,3 millones murieron por esta causa.Más del 95% de las muertes por tuberculosis ocurrieron en países de ingresos bajos y medianos, y esta enfermedad es una de las tres causas principales de muerte en las mujeres entre los 15 y los 44 años.En 2012, se estima que 530 000 niños enfermaron de tuberculosis y 74.000 niños seronegativos murieron de tuberculosis.La tuberculosis es la causa principal de muerte de las personas infectadas por el VIH, pues causa una quinta parte de las defunciones en este grupo.La tuberculosis multirresistente se ha encontrado en casi todos los países estudiados.Aunque lentamente, está disminuyendo el número anual estimado de personas que enferman de tuberculosis; ello quiere decir que el mundo está en camino de cumplir el Objetivo de Desarrollo del Milenio consistente en detener la propagación de esta enfermedad de aquí al año 2015.La tasa de mortalidad por tuberculosis disminuyó un 45% entre 1990 y 2012.Gracias a las estrategias DOTS y Alto a la Tuberculosis recomendadas por la OMS, se calcula que se habrían salvado unos 22 millones de vidas.
OMS, Marzo 2014
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Reparación
Estímulo inflamatorio
Destruccióntisular
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Infecciones persistentes
Infecciones agudasno resueltas
Infecciones crónicasde novo
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Enfermedades inflamatorias inmunes Agentes tóxicos no degradables
Artritis reumatoideLESEsclerosis MúltipleHashimotoGastritis x H pylorii
CarbónSílicaAsbestos
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PAMP
ARN bicatenarioADN CpGNFMLPLPSGp Bacterianas
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Overview of the pattern-recognition receptor system of phagocytes, including the TLR family.
Dale D C et al. Blood 2008;112:935-945
©2008 by American Society of Hematology
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CD14
TLR -4
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CD14
TLR-4
LPS
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TCR
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TCR
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TCR
CD 40 CD 40L
B7 CD 28
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CD 40 CD 40L
B7 CD 28
T-bet
STAT-1
IFN g
NK
STAT-4
Th1
TCR
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Th1 IFN g
HLA
iONS
TNF
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INOsi
IFN g
CD 40L = CD40
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TGFb IL-2
T-reg
CD4+
CD4+, CD25+ FOXP3
CTL-4GITR
STAT-5
IL-10 IL-35TGFb
CPA
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Th17CD4+
T-netGATA-3
IL-17 IL-35IL-22/IL-26GM-CSFIL- 21/TGFb
RORaSTAT-3IRF-4Runx-1
CXCMMPRANK-L
IL-1bIL-6
CCL-20CXCL-10
CCR-6
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Th17
Artritis reumatoidePsoriasisEsclerosis en PlacasEnf inflamatoria intestinal
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Th17 T-reg
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Ca++
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3 semanas
Th1 IFN g
IL-12
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TLR-2
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Chensue S. Frontiers in immunol, 2013, feb
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The schistosoma granuloma, friend or foe. Hams et al. Frontiers in immunol 2013, April 13
CD 4 deplecionado Normal
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Lacto N Fucopentosa
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Normal inmunocompetente inmunodeprimido
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EnfermedadesGranulomatosas
mycobacterias
espiroquetas
hongos Histoplasma capsulatumSchistosoma
TBCLepra
Treponema pallidum
B. De KochB de Hansen
desconocido
Sífilis
Sarcoidosis
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INMUNITAS
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PulmónPleuraGangliosRiñonHuesoSuprarenalesMeninges
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Gerhard Armauer Hansen1841-1912
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Th
IL-2IFNg
Ag + AcCI
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Aspergiliosis
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Enfermedad por arañazo de gato ( Bartonella henselae)
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Sarcoidosis
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Bahía Bustamante
Felices Pascuas !