Pechakacha presentation Apri lrums
Transcript of Pechakacha presentation Apri lrums
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Functional role of enzyme AMPK
April Irums
GRANT PROPOSAL
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What is AMPK?
AMP-activated protein Kinase
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More On AMPK…
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What Does AMPK Really DO?
• AMPK aids in efficient fatty acid oxidation. (FAT LOSS!)
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Heart & Liver • protein synthesis
• insulin resistance
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How Can We Benefit From AMPK?
Activated with exercise
Facilitates stronger heart muscles
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How Can We Benefit From AMPK?
Cardiac Hypertrophy
Diabetes
Faulty hormone signalling
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What Do We Already Know?
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We Also know That….
Mitochondria
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Hypothesis
Increased AMPK levels in the body will
increase mitochondrial density in type 1 muscle fibres and
myocytes
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How Are We Going To Test This?
Examine Samples
AMPK Levels within Samples
Prolonged Exercise
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Control Group
NO exercise!Sedimentary Lifestyle
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Experimental Group
Use of Biopsy equipment
30 days to exerciseIncrease Heart Rate
Measure AMPK Levels
Rat Food
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How Will We Do This?
Muscle and Heart Biopsy
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Procedure
SUPER TINY SCAR!
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Main Goal
Figuring out the functional role of AMPK in the body!
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What We Expect To See
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Heart Patients
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Problems With Weight
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Significance