Virus VIH
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INMUNOLOGÍA CLINICA
LIBIA MITSUKO SOTO VERA
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Virus: Partícula infecciosa intracelular obligada
que consta de un genoma de ácido nucleico simple en una cápside proteica, rodeada de una envoltura de membrana.
Ciclo vital necesita de la maquinaria metabólica de la célula invadida para
replicar su material genético, produciendo muchas copias del virus original.
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Grupo: VI (Virus ARN monocatenario retrotranscrito)
Familia: Retroviridae
Género: Lentivirus
VIH -1 VIH -2
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Descubrimiento 1981-1983-1984
-lymphadenopathy-associated virusL. Montagnier-human T lymphotropic virus type IIIR. Gallo
**human immunodeficiency virus
Zoonosis SIV [35 especies primates]-SIVcpz VIH-1 M N O -SIVsm VIH-2 [mangabeye gris]
Salto de barrera 3 veces!!!!!
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120 nm9.8 kb
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RTL integración ADN vírico.
gag [p55]p24, p17, p6, p7.
pol transcriptasa inversa, proteasa, integrasa, ribonucleasa.
env gp120, gp41.
*vif infecciosidad [APOBEC3G]
*vpr ADN vírico al núcleo.
tat alargamiento productos.
rev salida ARN vírico.
*vpu disminuye expresión CD4.
*nef reduce CD4 y CMH I. Liberación virus.
* accesorios
regula
estructura
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72 espiculas
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Sexual Parenteral Vertical
Células infectaLinfocito T CD4Macrófagos.Células dendríticas. Células dendríticas foliculares.
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TCD4
Macrófagos
Linfocitos T memoria
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