Land of opportunities for biosciences startup companies
Bilbao Bizkaia Startup
Strengths and drivers of Bilbao Bizkaia for biosciences startups
Macroeconomic Situation
Strengths
Entrepeneur driven public institutions
Drivers
Strategical Position Friendly towards invest-ment
Market Strength Biosciences Incubators, space for entrepreneurs
R&D&i Investment, introducing your best partners
Human Capital Access to the most talented human capital
Infrastructures and Connectivity
International events related to biosciences economy
Working and Living in Biscay Public advisory, all you need is us
1 1
2 2
3 3
4 4
5 5
6 6
7 7
Strengths of Bilbao Bizkaia for Biosciences startups
1. Macroeconomic Situation
Population
Foreign population
GDP per capita
Biosciences companies
Employment in biosciences industry
Metropolitan Bilbao: 1,100,000
7%
€ 28,461 122% EU average
70 Basque companies
26,500
Thanks to its location in the European Union, Bilbao Bizkaia is a strategic hub for the establishment of your biosciences startup
Direct flights to European cities
2. Strategical Position
ParisLondonBrusselsBerlinFrankfurtMunichDusseldorfSttutgartMilanRomeOsloLisbonAmsterdamBarcelonaMadridIstanbulGenevaManchester
3. Market Strength
Spain´s 3rdstrongest region for
foreign direct investment, behind
Madrid and Catalonia Almost 700 foreign companies settled in the Basque Country
700
People Employed in FDI companies = 11% of working
population
61.000
2008
2009
2010
2011
2012
2013
500 M
1000 M
999 MBasque Gross Investment Flow
3. Market Strength
Almost
300 companies involved
1,632 employees
211M exports
31M investment R&D&i
268M turnover
Basque Biocluster exerts itself to stay a dynamic and open association that reflects the goals of its members
Health-related (human or animal) biotechnologies
Bio-solutions for agro/food chains and environmental safety
Advanced materials and engineering
Turn-key lab/plant construction and systems
BASQUEBIOCLUSTER
First region in Spain according to
GDP Invested in R&D&i2,19%
Above EU 2020 objectives
More than € 170 mill. per year allocated for Research, Development and Innovation in Bilbao Bizkaia
Basic & excelence research centresInnovation
Support Sub System
University and
Scientifici Sub-System
Technological Development Sub-System
Centres for cooperative research
Technological centres
Research & innovaction bussiness units
Laboratories & health r+d centres
Intermediate bodies
Supporting infraestructures
Universities
Rese
arch & Development & Innovation
Basque Ecosystem: Biosciences Sect
or
34
28
14
64
19
9
7
4. R&D&i
Technology Park of Bizkaia
Stablished companies 219
Workforce 7,647
R&D employees 27%
Global income € 2,455 mill.
Advanced science, technology and innovation system.
4. R&D&i
Specialised Technology and Research Centres: key factor in industrial competitiveness
Technology Centres Research Centres
Key research areas:
CIC bioGUNECIC biomaGUNECIC microGUNECIC nanoGUNEBIOEFBiocrucesOnkologikoa, cancerCITA, AlzheimerInbiomed, Regenerative Medicine
Personalised medicine and diagnostics.
Regenerative medicine.
Drug discovery. Medical and surgical devices.
CNS & different diseases
Biosensors and analytics.
Equipment and instrumenta-tion.
Agrochemical uses of Biotechnology.
123M€ turnover
1,831 Staff
Members
105M€ turnover
145 patents
1,310 Staff
Members
1,280 researchers
335 patents
5. Human Capital
The Basque University Education is referent within the European Higher Education Area.
3rd European Region with the
highestnumber of university graduates
67,551 University Students
8,769 biosciences sector related university studies
Young people with university degree
Bizkaia 43%Europe 24%
Deusto
MONDRAGONUNIBERTSITATEA
5. Human Capital
• Human Nutrition and Dietetics• Dentistry• Nursing• Pharmacy• Environmental Engineering• Chemical Engineering• Industrial Chemical Engineering• Manufacturing Ecotechnologies• Biomedical Engineering
• Theoretical chemistry and computational modelling
• Advanced materials engineering• Chemical engineering• Control engineering, automation and
robotics• Engineering physics• Environmental engineering• Renewable materials engineering• Research in environmental engineering• Photovoltaic devices and systems• Sustainable energy engineering
• Biology• Biochemistry and Molecular Biology• Biotechnology• Science and Food Technology• Environmental Sciences• Physics• Geology• Mathematics• Chemistry• Medicine
• Forensic analysis• Biomedical engineering• Biomedical research• Microbiology and health• Molecular biology and biomedicine• Neuroscience• Pharmacology, development, evaluation
and rational use of medicines• Food quality and safety• Nutrition and health• Applied chemistry and polymeric
materials• Nanoscience• New materials• Physics and materials technologies• Synthetic and industrial chemistry
Degree
Master
Deusto
MONDRAGONUNIBERTSITATEA
6. Infrastructures and connectivity
Metro and tram:
1.000 million users per year. Three minutes frequency. Complete coverage of metropolitan area.
High Speed Train,
will start operating in 2018: Madrid in 2 hours, Paris 5 hours.
Road Connections:
Excellent transport links, which connects all municipalities in less than 40 minutes by road or public transport.
Airport:
more than 4 million passengers per year. 10 minutes from Bilbao city center (12 Km).
Bilbao international airportRoad connectionsNetwork of railway linesMetro & city tram
6. Infrastructures and connectivity
Animal facilities and animal models
Cell Reprogramming and Differentiation core facility
Structural Biology Platform (NMR, protein crystallisation, X-ray, electron microscopy)
Pharma and biomanufacturing
Basque Biobank, O+ehun (brains, tumours, peripheral blood - DNA, RNA, etc. - and other fluids)
Metabolomics platform, mass spectrometry based
Inbiobank (adult stem cells and primary cells), node of the National Bank of Cell Lines
Genome analysis and gene silencing platforms
Proteomics core facilities
Molecular Imaging Facility (radiochemistry, MRI, SPECT, PET, CT, optical tomography)
Dedicated biomedical Effectiveness Demonstration Unit and other clinical resources
Innovative infrastructures at the service of talent
6. Infrastructures and connectivity
€ 72 mill. public budget allocated for the digital agenda.
Cloud Computing boosted from the public institutions
Broad Band access 95% of the population
Secure and trustable network
88% of the population access NGAs and 3G /4G technologies.
Cutting edge TIC infrastructures that cover all Bilbao-Bizkaia.
• Human Development Index Bizkaia• Above UE average rate, 0,738.
• High quality health care• Longest life expectancy in the EU.• Free and universal health system,
reference as a quality service.
78,2 85,1
7. Working and Living in Bilbao-Bizkaia
1st
LivCom Prize in the category of Enhancement of the Natural and Built Landscapes
1st
Lee Kuan Yew World City Prize 2010 (Nobel Prize of
Cities)
1st
Best Urban Practices Award
(Expo 2010)
1st
Città d´Acqua, Biennale
di Venezia Architecture
7. Working and Living in Bilbao-Bizkaia
1 M annual visitors at Guggenheim Museum
Cultural Assets declared World Heritage by UNESCO
Beach 10 minutes away from city centre
53% of its surface covered with trees.
Natural Assets declared as Biosphere Reserve by UNESCO
Bilbao is the 3rd most sustainable City in Spain
28 Michelin Stars in 2014
Bilbao is a reference in the European Art Network, and it complements the Bilbao-Bordeaux-Madrid Ant Axis.
Culture Nature Gastronomy
Drivers for a biosciences startup in Bilbao Bizkaia
1st
City with the best e-Administration in Spain according to the Internet Users Association (2010)
1st
Most transparent city in Spain in 2008, 2009, 2011 and 2012 according to Transparency International
1st
Rigorous economic policies and strategic budget to ensure a stable economic network (zero debt, paid in 30 days)
4th
Southern European city in the overall and FDI strategy categories in the FDI European Cities and regional of the future ranking (2014)
1. Entrepreneur driven public institutions
Openness
Transparency
Security
Investment
Winner of the EPSA-European Public Service Award (2011)
1. Entrepreneur driven public institutions
Three public companies committed to digital contents startups in Bilbao Bizkaia.
Advice in obtaining licenses and permits
Obtaining visaConnectivityTrademarkPatenting
Funding & subsidiesConstitution (PAE)LocationAdvisoryHiring
Expedited incorporation: 2-3 days. Cheap incorporation: 100 € Accompanying notary signatureAdministrative documentationAdvice on legal forms
A consultant beside you 24/7
Centralised Point to help entrepreneurs
2. Friendly towards investment
Bizkaia legislates on direct taxes and establishes tax incentives and deductions for its businesses.
Research Development 30-50%
New Non-Current Assets 10% (5% in asset improvement)
Projects involving sustainable taxation 10-30%
Patent Box 30-60% (acquired or developed)
Creation of employment 4,900€ per person
Incentives related to funding (all companies)
Technological Innovation 15-20% (with Technological Centres)
Tax Incentives for companies investing in startups:• Reduction in the tax base (60% of the invested amount)• Purchase of shares: maximum 100.000€ per investment
General tax 28%
Reduced to 24% for SMEs
Tax Deductions
3. Biosciences Incubators, space for entrepreneurs
An advanced business incubator specialised in value added sectors
Kabi 612.5.600m2 (4.5€/m2/month) 20MB
Elkartegiak. (3-9€/m2/month) 20MB
High Value added sectors and technologies: Bio-micro-nano technologies, Clean technologies and Advanced manufacturing
Specialitation
Fully equiped with workrooms and laboratories for the development of the industrial and research activities.
Installations
Focused on the growth and the continuity of the companies: Acceleration, access to experts, training, investment rounds.
Services
4. Investment, introducing your best partners
Specific public funding for every stage of the company life cycle.
110kproject concept
250kSeed Capital
Bizkaia
2,000kEzten
500kEkintzaile XXI
500kLanpar
500kElkano XXI
5,000-4,0000kEkarpen
1500kGauzatu
180kCorporate
constitution100kBasque Fondo
25kMicro credits
400kBasque Fondo II
95kIncorporation
250kElkartzen
250kGaitek
120kInternatio-nalisation
1,000kEtorgai
1,000kBideratu
Grant
Loan
Capital
REV
ENU
E
TIME
Angels, FFF
Seed Capital
Early Stage
Valley of Death
VCs Acquisitions/Mergers& Strategic Alliances
Pre-Seed Capital
Later Stage
50kInnovative
projects
70kEquipment Purchase
* Maximum amounts for each funding tool. Some of them would be subject to the European minimis rule.
4. Investment, introducing your best partners
Private funding agents in Bilbao Bizkaia are extremely proactive in searching startups to invest in.
200kBusiness Angels
Network
150kSeed Funds
300kENISA
Entrepeneurs
>150kCDTI
Innovation
50kFinancial Entities
25kSocial
Entities
Endorsament
Loan
Capital
REV
ENU
E
TIME
Angels, FFF
Seed Capital
Early Stage
Valley of Death
VCs Acquisitions/Mergers& Strategic Alliances
Later Stage
250kSpecialised
funds
1,500kMutual Guaran-
tee Societies
Private investment funds operating in Bilbao Bizkaia:
START DMCArgi Industrial Partners / UPLIFT S.L.MicroWave VenturesEmprendizaSamsung Venture InvestmentKereon partnersAbra Invest S.L.Crecer +Bulka Business AngelsInceptionOnzaVitamina kEntrecanales Sitka CapitalFaraday Ventures PartnersOnetoOne Corporate FinanceDUMA AsociadosTaldeEkarpenCaixa Capital Risk
* Maximum amounts for each funding tool. Some of them would be subjet to the European minimis rule.
Finance Advice Training Prizes
Micro credits and other instruments
BBVA Innovation Centre
Yo soy empleo BBVA Open Talent
Micro credits and other instruments
Startup advice BBK Fundazioa BBK Ideas competition
Diverse financial products
Entrepreneur advice Gaztelanbidean New business ideas competition
Caixa Capital RiskMicroBanck
Advice for different entrepreneur profiles
Entrepreneurship programmes
XXI Entrepreneur awards
Financial instruments Specialized advice Trainning Courses Bstart up
4. Investment, introducing your best partners
Financial institutions in Bilbao-Bizkaia offer much more than just funds.
5. Access to the most talented human capital
A digital contents company can take advantage of tax benefits from employement.
Public Institutions promote Training on the job
Subsidies for training and development of human capital
1M€ aids/year.120 professionals/year.
30% of the gross salary (Up to € 9,000 per person).Up to 90.000€ subsidy per company when employing staff.
Enterprises paying Social Security generate a credit in order to invest in training for employees.
Public Institutions also offer subsidised training programmes for Basque employees, including specific programmes in R&D&i.
Up to € 20,000 on Human capital training and specialitationUp to € 30,000 /person for hiring senior R&D&I employeesUp to € 20,000 /person for hiring junior R&D&I employees
Through our subsidiary Bizkaia Talent, we attract foreign qualified personnel.
Benefits of hiring talent
* In addition to all thisbonus in Social Security Tax for researchers: 40% of the company¨s contribution for common contingenices
5. Access to the most talented human capital
No work permit needed
Work permit + Visa
Foreign Employees
Job Offer Company Registration
Residence and Work Permit Residence and Work Permit
Visa Visa
Foreign Entrepreneurs
UENon UE
14/2013 Law for Entrepreneurs support and their interntionalization
WHO:InvestorsEntrepreneursHighly qualified professionalsR&D&I developmentIn company transfer
WHERE (one-stop-shop):Residence authorisation: Strategic Collective Unit-Ministery (resolution in 20 days)Visa: Spanish consulate country of origin (resolution in 10 days)
HOW:Passport or identity document (applicants must be over 18)Medical insurance accreditation documentCriminal record certificateEconomic means accreditation
6. International events related to biosciences economy
International events in Bilbao
Facilities to host international events
7. Public Advisory, all you need is us
For further information contact: [email protected]
SPRI S.A. is the Business
Development agency of the
Autonomous Region of the
Basque Country, to promote
the country as an attractive
place to invest in, and the
promotion of business
dealings between foreign
and Basque companies.
Beaz S.A.U. is the company
of the Department of
Economic Promotion of
Biscay´s Provincial Council,
responsible for the
development of innovative
business projects and the
fostering of high growth
startups, both local and
foreign.
Bilbao Ekintza is a
Local Business Public
Entity (EPEL) created to
generate economic and
social wealth in the city,
enhancing its capabilities
as a destination for
investment, business
creation and growth,
attracting visitors and
talent.
European Union
European RegionalDevelopment Fund