Post on 26-Jan-2017
Functional role of enzyme AMPK
April Irums
GRANT PROPOSAL
What is AMPK?
AMP-activated protein Kinase
More On AMPK…
What Does AMPK Really DO?
• AMPK aids in efficient fatty acid oxidation. (FAT LOSS!)
Heart & Liver • protein synthesis
• insulin resistance
How Can We Benefit From AMPK?
Activated with exercise
Facilitates stronger heart muscles
How Can We Benefit From AMPK?
Cardiac Hypertrophy
Diabetes
Faulty hormone signalling
What Do We Already Know?
We Also know That….
Mitochondria
Hypothesis
Increased AMPK levels in the body will
increase mitochondrial density in type 1 muscle fibres and
myocytes
How Are We Going To Test This?
Examine Samples
AMPK Levels within Samples
Prolonged Exercise
Control Group
NO exercise!Sedimentary Lifestyle
Experimental Group
Use of Biopsy equipment
30 days to exerciseIncrease Heart Rate
Measure AMPK Levels
Rat Food
How Will We Do This?
Muscle and Heart Biopsy
Procedure
SUPER TINY SCAR!
Main Goal
Figuring out the functional role of AMPK in the body!
What We Expect To See
Heart Patients
Problems With Weight
Significance