SEMINARIO Infecciones osteoarticulares 2012

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Infecciones Infecciones osteoarticularesosteoarticulares

Sandra Milena Acevedo RuedaMD Residente 2do año, Medicina Interna UNABNoviembre de 2012

Artritis sépticaArtritis séptica

• 2-10/100.000

• Artritis reumatoide: 28-38/100.000

• Mortalidad: 1-7%

• Morbilidad: 50%

• Artroscopias: 0.14%

• Factores predisponentes (20% no identificables)

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Estudio de cohorte, pacientes con artritis aguda: edad mayor a 80 años, diabetes

mellitus y artritis reumatoide fueron asociados con incremento en la incidencia de artritis séptica (likelihood ratios: 3.5, 2.7, y 2.5,

respectivamente)

Kaandorp CJ, van Schaardenburg D, Krijnen P, et al. Risk factorsfor septic arthritis in patients with joint disease. A prospectivestudy. Arthritis Rheum. 1995;38:1819-1825.

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

• Mordeduras – Gatos– Perros– Humanos– Ratas

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

• Monoarticular 80-90%

• Rodilla 50%

• Poliarticular: AR, DM, inmunosupresión

• Cuadro típico: dolor, limitación (1 a 2 sem)

• Fiebre: 47% (S: 57%)

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

• Cultivo (80-90%)

• Gram (50%)

• Hemocultivos (50-70%)

• Rx, Ecografía

• Gammagrafía, TAC, RMN

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

DXCO ASPECTOCOÁGULO

DE FIBRINACOÁGULO

DE MUCINALEUC POR

mm3 PMN (%)GLUCOSA (%

DEL NIVEL DE LA

SANGRE)

Normal Transparente Negativo Bueno < 200 < 25 < 100

Osteoartros Ligeramente turbio

Pequeño Bueno < 2 000 < 25 < 100

Artritis traumática Sanguinolento

Pequeño Bueno 2 000 < 25 < 100

Artritis reumatoideArtritis reumatoide

Turbio Grande Regular a pobre

5 000 a50 000

> 65 75

Gota aguda Turbio Grande Regular a pobre

5 000 a50 000

> 75 90

Artritis séptica

Purulento Grande Pobre 50 000 a200 000

> 80 < 50

Artritis tuberculosa

Turbio Grande Pobre < 25 000 Variable < 50

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Diagnostic Parameters of Synovial Fluid White BloodDiagnostic Parameters of Synovial Fluid White BloodCell Count and Percent Polymorphonuclear Cells inCell Count and Percent Polymorphonuclear Cells in

Patients with Septic ArthritisPatients with Septic Arthritis

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Gonococcal infection. Pustular lesion overlying the fifth toe in a patient with disseminated gonococcal infection.

Enfermedad gonocóccica diseminada– Artritis gonocóccica– Dermatitis, tenosinovitis, poliartralgias

Artritis gonocóccica:

Mujeres, 1970’s, disminución en 75%

Gram 25%, cultivos 30%

Sx Reiter

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

En artritis gonocóccica: 7-10 días

Otros: 2 a 4 semanas

Anaerobios: Mordeduras

Corticoides sistémicos

Virus

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Chronic arthritis of the knee due to Chronic arthritis of the knee due to Mycobacterium Mycobacterium tuberculosis.tuberculosis.

OsteomielitisOsteomielitis

EPIFISIS

PLACACRECIMIENTO

METÁFISIS

CAPSULA ARTICULAR

VASOEPIFISIARIO

ARTERIANUTRICIA

CAPSULA ARTICULAR

ARTERIA

METAFISIARIA

ARTERIA

NUTRICIA

PERIOSTIO

CORTEZADIÁFISIS

METÁFISIS

LAGOSVENOSOS

EPIFISIS

PLACA EPIFISIARIA

Inflamación del hueso producida por un agente infeccioso. Puede

permanecer localizada o extenderse por el hueso para afectar medula,

cortical, periostio o los tejidos blandos circundantes.

Campbell, Cirugia ortopédica. Terry Canale, et all. 11ª edición. 2007. Mosby

Lew y WaldvogelLew y Waldvogel

• Duración - Aguda - Crónica

• Fuente de infección - Hematógena- Contigua- En presencia de insuf. vascular

Osteomyelitis in Long Bones, JBJS, J Bone Joint Surg Am. 2004;86:2305-2318. Lazzarini, Mader, Calhoun

Vías de infección

Osteomielitis hematógena

Luego de Bacteriemia.

Más frecuente en niños

y ancianos

Afecta a metáfisis de

huesos largos y vértebras.

También por uso de

catéteres y uso de drogas

e.v.

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Vías de infección

Osteomielitis por foco contiguo

• Luego de fractura abierta ó de cirugía. Asociada a protésis.

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Vías de infección

Osteomielitis por

insuficiencia

vascular

En diabéticos e insuficientes

Vasculares

Afecta principalmente el pie

Curso crónico e insidioso.

Suele no haber dolor.

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Osteomyelitis in Long Bones, JBJS, J Bone Joint Surg Am. 2004;86:2305-2318. Lazzarini, Mader, Calhoun

Cyerny y MaderCyerny y Mader

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Cyerny y MaderCyerny y Mader

Osteomyelitis in Long Bones, JBJS, J Bone Joint Surg Am. 2004;86:2305-2318. Lazzarini, Mader, Calhoun

Cyerny y MaderCyerny y Mader

Signos clínicosSignos clínicos

• Dolor

• Edema

• Fistula

• Febricula o fiebre

• Exudado

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Estudios Estudios

• Rx AP, lat y oblicuas (10 a 14 días)

• Fistulografía

• Gammagrafía (Galio, Tec99, Indio 111)

• Tomografía

• CH, VSG, Proteínas, Tiempos, Uroanálisis, cultivo, antibiograma, hemocultivos, cultivo de fragmento óseo, estudio histopatológico

Contrary to common belief, swab cultures from draining wounds and sinus tracts can be of diagnostic benefit for two

main reasons. First, the identification of certain resistant microorganisms (e.g., methicillin-resistant S. aureus,

vancomycin-resistant enterococcus) indicates the need for infection control measures. Second, the isolation of S. aureus from superficial cultures has a high degree of

correlation with deep cultures

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

T2-weighted axial MR image of the left tibia reveals abnormality of the midportion and proximal portion of the tibia (arrows). During surgery, there was a significant amount of purulence and osteomyelitic bone present. Cultures grew Pseudomona aeruginosa.

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

CT reconstruction image of a nonunited femur fracture6 months after intramedullary nailing. Surgical cultures grewPseudomonas aeruginosa and Propionibacterium acnes.

Principios quirúrgicos en Osteomielitis

• Adecuado drenaje de los tejidos afectados• Desbridamiento • Remoción material• Manejo del espacio muerto• Cierre completo de la herida• Estabilización fractura

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Secuestro: son fragmentos de hueso muerto, y

actúan como un cuerpo extraño dentro de la

lesión.

Involucro: Son capas de hueso nuevo

en crecimiento, se forman alrededor del hueso

existente, y pueden alterar la cicatrización.

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Angiogram of lower extremity reveals

occludedbypass graft in a patient

with diabetes mellitus presenting with

chronic gangrene and osteomyelitis of the foot.

Angiogram of lower extremity reveals

occludedbypass graft in a patient

with diabetes mellitus presenting with

chronic gangrene and osteomyelitis of the foot.

Osteomielitis aguda

• Niños (2 años)

• Metafisis

• Hematógena

• Infección – reacción inflamatoria – necrosis isquémica de la médula – necrosis del hueso - absceso

Osteomyelitis in Long Bones, JBJS, J Bone Joint Surg Am. 2004;86:2305-2318. Lazzarini, Mader, Calhoun

Fuentes

• Foco primario :

- Dentales- Vías urinarias- Respiratorias- Otras

Osteomyelitis in Long Bones, JBJS, J Bone Joint Surg Am. 2004;86:2305-2318. Lazzarini, Mader, Calhoun

• A: INFANCIA

• B: LACTANTE

• C: ADULTO

• A: INFANCIA

• B: LACTANTE

• C: ADULTO

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Antimicrobial Therapy of Antimicrobial Therapy of Osteomyelitis in Adults forOsteomyelitis in Adults forSelected MicroorganismsSelected Microorganisms

Key wrote: “continuous drug over a longperiod of time will lessen the amount of

discharge, but it will not curethe disease because it cannot sterilize dead bone or cavities with necrotic content and

rigid walls.”

Osteomyelitis in Long Bones, JBJS, J Bone Joint Surg Am. 2004;86:2305-2318. Lazzarini, Mader, Calhoun

MANDELL, DOUGLAS, AND BENNETT’S PRINCIPLES AND PRACTICE OF INFECTIOUS DISEASES. Seventh Edition. Copyright © 2010

Indicaciones Cirugía:

Abscesos óseos subperiosticos ó tejido blandoBacteriemia persistente post a 48-72 de ttoDolor, edema ó fiebre post a 72 de ttoDesarrollo de fistulas Presencia de secuestros óseos